Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 405-370-0 | CAS number: 6334-25-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V (Limit test)
- GLP compliance:
- yes
- Limit test:
- yes
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Substance ground and moistened with 0.85%saline
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- Male: 5000 mg/kg; number of animals: 6; number of death: 0
Female: 5000 mg/kg; number of animals: 6; number of death: 0 - Clinical signs:
- Signs of toxicity related to dose levels:
No deaths and no signs of systemic toxicity were observed
Erythema was observed on day 1, but was not scored. (Body weight loss of 5-25% was seen in 2 animals during the first week; this was attributed to stress produced by the collars worn throughout the study) - Gross pathology:
- Effects on organs: No treatment-related macroscopic findings were observed in internal organs
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
