19-Norpregn-5(10)-ene-21-nitrile, 17-hydroxy-3-oxo-, (17.alpha.)-

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2002

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

no

Type of method:

effusion method: vapour pressure balance

Remarks:

(Knudsen effusion method)

Temp.:

25 °C

Vapour pressure:

< 0.001 Pa

Remarks on result:

other: the vapor pressure value of 0.001 Pa equals an evaporation rate of 0.014 ¿g/s

Since the evaporation rate of the mixture was below the value derived from the lower limit of the vapor pressure range recommended for the use of a vapor pressure balance (10^-3Pa, EC Testing Guideline A.4) it can be assumed that the vapor pressure of the mixture is lower than 10^-3Pa.

In addition the mass spectra of the vapor escaping from the Knudsen cell show only masses m/e < 200 indicating that impurities with low molecular weights were evaporated from the mixture.

Conclusions:

The vapour pressure of the substance is lower than 0.001 Pa at 25 °C.

Executive summary:

The vapor pressure was determined using a screening method based on the detection of the evaporation rate from a Knudsen cell of a vapor pressure balance at 25°C. Since simplified experimental conditions are also acceptable the test substance was mixed with one other compounds. From both test substances low or very low vapor pressures were expected. For this reason the experiments consisted in the measurement of the evaporation rate of the mixture from a Knudsen cell a 25°C. Since the evaporation rate of the mixture was below the value derived from the lower limit of the vapor pressure range recommended for the use of a vapor pressure balance (10-3Pa, EC Testing Guideline A.4) it can be assumed that the vapor pressure of the mixture is lower than 10 ^-3Pa. Considering this fact, the vapor pressure of the single compounds in the mixture has also to be lower than 10-3Pa.

Description of key information

The vapour pressure of the substance was measured to be <0.001 Pa at 25 °C.

Key value for chemical safety assessment

Vapour pressure:

0.001 Pa

at the temperature of:

25 °C

Additional information

"Should read: < 0.001 Pa"

The substance is considered to be non volatile.