Registration Dossier
Registration Dossier
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EC number: 925-462-9 | CAS number: 1182723-73-4
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1988
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1988
- Reference Type:
- study report
- Title:
- Unnamed
Materials and methods
- GLP compliance:
- yes
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
Constituent 1
Test animals
- Species:
- other: dogs, mice
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 10 mg/kg bw/day (actual dose received)
- Basis for effect level:
- other: Beagle dogs (2 males and 2 females in dose groups of 0, 10, 40, and 160 mg/kg bw), 4 week daily dosing with Bay u 3405 capsules
- Dose descriptor:
- NOAEL
- Effect level:
- 180 mg/kg bw/day (actual dose received)
- Basis for effect level:
- other: mice (10 males and 10 females in dose groups of 0, 5, 30, 180, and 300 mg/kg bw), 78 days daily dosing with Bay u 3405 via gavage
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
