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EC number: 206-525-3
CAS number: 352-87-4
TFMEA is likely to be readily absorbed by all routes. The ester is rapidly hydrolysed by carboxylesterases to methacrylic acid (MAA) and 2,2,2-Trifluoroethanol. The primary metabolite, MAA, is subsequently cleared rapidly from blood by standard physiological pathways, with the majority of the administered dose being exhaled as CO2. 2,2,2-Trifluoroethanol is oxidised to Trifluoroacetic acid and renally excreted. Based on physicochemical properties, no potential for bioaccumulation is to be expected.
physicochemical properties of TFMEA (log P = 2.3) and the molecular
are in a range suggestive of absorption from the gastro-intestinal tract
subsequent to oral ingestion.For
chemical safety assessment an oral absorption rate of 100% is assumed as
a worst case default value in the absence of other data.
on a QSAR Prediction of Dermal Absorption (extract from Heylings JR,
2013) TFMEA is predicted on the basis of their molecular weight and
lipophilicity to have a relatively low ability to be absorbed through
the skin. The predicted flux was 0.144 µg/cm²/h.
for chemical safety assessment, a dermal absorption rate of 100% was
assumed as worst case default value.
has a vapour pressure of 2200 Pa at 20°C. Thus, inhalation is a likely
route of exposure. For chemical safety assessment an inhalative
absorption rate of 100% is assumed as a worst case default value in the
absence of other data.
a small molecule a wide distribution can be expected.
No information on potential target organs is available.
hydrolysis has been established as the primary step in the metabolism of
methacrylate esters. Carboxylesterases are a group of non-specific
enzymes that are widely distributed throughout the body and are known to
show high activity within many tissues and organs, including the liver,
blood, GI tract, nasal epithelium and skin (Satoh & Hosokawa, 1998;
Junge & Krish, 1975; Bogdanffy et al., 1987; Frederick et al., 1994).
Those organs and tissues that play an important role and/or contribute
substantially to the primary metabolism of the short-chain, volatile,
methacrylate esters are the tissues at the primary point of exposure,
namely the nasal epithelia and the skin, and systemically, the liver and
blood. For TFMEA mostly the same would be the case except that because
of the lower vapour pressure and hence lower likelihood of inhalation
exposure the involvement of the nasal epithelium is less likely.
hydrolysis of TFMEA would result in Methacrylic acid and2,2,2-Trifluoroethanol.
2,2,2-Trifluoroethanol is expected to be oxidised to 2,2,2-Trifluoroacetaldehyde
and finally 2,2,2-Trifluoroacetic acid which can then be
excreted via the urine.
acid is cleared rapidly from blood by standard physiological pathways,
with the majority of the administered dose being exhaled as CO2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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