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Description of key information

ACD/Percepta model for acute oral toxicity on mouse and rat provides LD50predictions for mice and rat by oral administration route,based on the GALAS methodology. Reliability of predictions is estimated in terms of reliability index (RI),which ranges from0 to 1 and takes into account the similarity of the target with the training set compounds and the consistency of experimental values for similar compounds.

For 2-Benzyl-4-(dimethylamino)butanoic acid,ACD/Percepta provided anLD50prediction in mouse equal to 2300 mg/kg and an LD50prediction in rat equal to 2500 mg/kg. Both prediction wer assessed as moderate reliable being the reliability index equal respectiely to 0.56 and 0.68.

Key value for chemical safety assessment

Additional information

The prediction was provided on the substance2-Benzyl-4-(dimethylamino)butanoic acid (CAS 1613 -23 -6), the acid form of the substance in the object of the registration.

Justification for classification or non-classification