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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
calculation (if not (Q)SAR)
Remarks:
estimated by calculation
Adequacy of study:
supporting study
Study period:
29-11-2010/17-06-2013
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Conducted at a GLP accredited laboratory
Qualifier:
no guideline available
Principles of method if other than guideline:
Visual observation
Medium:
n-octanol
Solubility:
> 1.067 other: g/mL
Temp.:
25 °C

The aliquot of test substance appeared to be completely dissolved by visual observations after the addition of 0.1 mL n-octanol, therefore no additions beyond 0.4 mL n-octanol were made. The results from the preliminary solubility estimate in n-octanol are presented in table. The solubility of the test substance in n-octanol, as determined by visual observation, was listed as greater than 1.067 g/mL or 1067 mg/mL.

Table: Visual n-octanol solubility

 Test substance

                Solubility Observations (Yes/No/NA)

Total Volume (mL)

 Solvent   Weight (g)  0.1  0.4  1  2  10  100
 n-octanol  0.1067  Yes  Yes  NA  NA  NA  NA
Conclusions:
The solubility of the test substance in n-octanol, as determined by visual observation, was found to be greater than 1.067 g/mL or 1067 mg/mL.

Description of key information

The solubility of the test substance in n-octanol, as determined by visual observation, was determined to be >1.067 g/mL.

Key value for chemical safety assessment

Additional information

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