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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
SIDS INITIAL ASSESSMENT PROFILE for 2-aminoethanol
Author:
OECD
Year:
2013
Bibliographic source:
OECD SIDS INITIAL ASSESSMENT PROFILE

Materials and methods

Principles of method if other than guideline:
Data published on skin corrosion/irritation studies for 2-aminoethanol, neutral form of ethanolaminium cation.
GLP compliance:
not specified
Remarks:
Data published. No detailed information about GLP compliance.

Test material

Constituent 1
Chemical structure
Reference substance name:
2-aminoethanol
EC Number:
205-483-3
EC Name:
2-aminoethanol
Cas Number:
141-43-5
Molecular formula:
C2H7NO
IUPAC Name:
2-aminoethanol
Test material form:
liquid

Test animals

Species:
other: laboratory animals

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Remarks on result:
other: corrosive to the skin

Applicant's summary and conclusion

Interpretation of results:
Category 1B (corrosive) based on GHS criteria
Conclusions:
2 -aminoethanol (MEA), the neutral form of ethanolminium cation, is considered corrosive to skin.