Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study under GLP conditions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report Date:
2009

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Batch PC5
Purity: 97.9 %

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
> 5.1
Temp.:
25 °C
pH:
7

Any other information on results incl. tables

The partition coefficient POWmay be estimated from the saturation concentrations in n-octanol and water by the following equation:

POW= cSoctanol / cSwater                                                         (2)

S= saturation

With the data obtained from the preliminary tests described in project 20080414.01 and in chapter 4.5.1 the partition coefficient was calculated as: log POWbetween 1.7 and 2.0. With the determined water solubility by means of the column elution method, which is a maximum value, the log POWof the test item amounts to 4.4 – 4.6. Due to this factthepartition coefficient n-octanol/water of the test item at room temperature was determined by the HPLC-method.

Also the program kowwinnt (part of episuite from SRC) was used for calculating the log POWof the test item. The EPI (Estimation Programs Interface) Suite was developed by the EPA´s Office of Pollution Prevention Toxics and Syracuse Research Corporation (SRC). The calculated value was 8.22 for the test item.

Applicant's summary and conclusion