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Link to relevant study record(s)

Reference
Endpoint:
basic toxicokinetics, other
Type of information:
other: Assessment based on physicochemical properties and toxicological data
Adequacy of study:
supporting study
Study period:
2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Objective of study:
absorption
distribution
excretion
metabolism
toxicokinetics
Principles of method if other than guideline:
Assessment based on physicochemical properties and toxicological data
GLP compliance:
no
Conclusions:
Disperse Yellow 114 would be absorbed primarily in gastrointestinal tract, while limited absorption via dermal and inhalation exposure can be expected at high doses. Systemic distribution would most likely occur along the gastrointestinal tract. Predominant route of excretion is expected to be through faeces, however, it may get metabolized to a more hydrophilic product and may also get excreted via urine at high doses.
Executive summary:

Disperse Yellow 114 would be absorbed primarily in gastrointestinal tract, while limited absorption via dermal and inhalation exposure can be expected at high doses. Systemic distribution would most likely occur along the gastrointestinal tract. Predominant route of excretion is expected to be through faeces, however, it may get metabolized to a more hydrophilic product and may also get excreted via urine at high doses.

Description of key information

Disperse Yellow 114 would be absorbed primarily in gastrointestinal tract, while limited absorption via dermal and inhalation exposure can be expected at high doses. Systemic distribution would most likely occur along the gastrointestinal tract. Predominant route of excretion is expected to be through faeces, however, it may get metabolized to a more hydrophilic product and may also get excreted via urine at high doses.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information