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EC number: 219-203-2 | CAS number: 2386-57-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Data Quality 100%. Data manually curated with highest confidence
Data source
Reference
- Reference Type:
- other:
- Title:
- iCSS CompTox Dashboard, Methanesulfonic acid
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 016
- Bibliographic source:
- https://comptox.epa.gov/dashboard/DTXSID4026422 (accessed September 01, 2016)
Materials and methods
- Type of study / information:
- High-throughput robotic screening
- Principles of method if other than guideline:
- Using a high-throughput robotic screening system, environmental chemicals and approved drugs (called the Tox21 10K library) were assessed for their potential to disrupt biological pathways that may result in toxicity.
Test material
- Reference substance name:
- Methanesulphonic acid
- EC Number:
- 200-898-6
- EC Name:
- Methanesulphonic acid
- Cas Number:
- 75-75-2
- Molecular formula:
- CH4O3S
- IUPAC Name:
- methanesulfonic acid
Constituent 1
Results and discussion
Any other information on results incl. tables
Methanesulfonic acid
Molecular Formula: CH4O3S
Average Mass: 96.1 g/mol
Monoisotopic Mass: 95.988115 g/mol
Structural Identifiers
IUPAC Name: Methanesulfonic acid
SMILES: CS(O)(=O)=O
InChI String: InChI=1S/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4)
InChIKey: AFVFQIVMOAPDHO-UHFFFAOYSA-N
No active results found for Methanesulfonic acid.
Assay Name |
Hit Call |
Top |
Scaled Top |
AC50 |
log AC50 |
Intended Target Family |
TOX21_AR_BLA_Agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AR_BLA_Agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AR_BLA_Agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_AR_BLA_Antagonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_AR_BLA_Antagonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_AR_LUC_MDAKB2_Agonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_AR_LUC_MDAKB2_Antagonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_Aromatase_Inhibition |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cyp |
TOX21_AutoFluor_HEK293_Cell_blue |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEK293_Cell_green |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEK293_Cell_red |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEK293_Media_blue |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEK293_Media_green |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEK293_Media_red |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEPG2_Cell_blue |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEPG2_Cell_green |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEPG2_Cell_red |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEPG2_Media_blue |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEPG2_Media_green |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AutoFluor_HEPG2_Media_red |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ELG1_LUC_Agonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
hydrolase |
TOX21_ERa_BLA_Agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ERa_BLA_Agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ERa_BLA_Agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_ERa_BLA_Antagonist_ratio |
INACTIVE |
7.31 |
0.221 |
0.160 |
-0.795 |
nuclear receptor |
TOX21_ERa_BLA_Antagonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_ERa_LUC_BG1_Agonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_ERa_LUC_BG1_Antagonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_GR_BLA_Agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_GR_BLA_Agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_GR_BLA_Agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_GR_BLA_Antagonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_GR_BLA_Antagonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_MMP_ratio_down |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell morphology |
TOX21_MMP_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_PPARg_BLA_Agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_PPARg_BLA_Agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_PPARg_BLA_Agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_TR_LUC_GH3_Agonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_TR_LUC_GH3_Antagonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_AhR_LUC_Agonist |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_ARE_BLA_Agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ARE_BLA_Agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ARE_BLA_agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_HSE_BLA_agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_HSE_BLA_agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_HSE_BLA_agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_p53_BLA_p1_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p1_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p1_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_FXR_BLA_agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_FXR_BLA_agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_FXR_BLA_agonist_ratio |
INACTIVE |
5.89 |
0.197 |
0.000855 |
-3.07 |
nuclear receptor |
TOX21_FXR_BLA_antagonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_FXR_BLA_antagonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_PPARd_BLA_agonist_ch1 |
INACTIVE |
822 |
0.292 |
253 |
2.40 |
background measurement |
TOX21_PPARd_BLA_agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_PPARd_BLA_agonist_ratio |
INACTIVE |
34.0 |
0.495 |
2.80 |
0.448 |
nuclear receptor |
TOX21_PPARd_BLA_antagonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_PPARd_BLA_antagonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_PPARg_BLA_antagonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
nuclear receptor |
TOX21_PPARg_BLA_antagonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_VDR_BLA_agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_VDR_BLA_agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_VDR_BLA_agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cyp |
TOX21_VDR_BLA_antagonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cyp |
TOX21_VDR_BLA_antagonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_ARE_BLA_agonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_HSE_BLA_agonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_p53_BLA_p1_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_FXR_BLA_agonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_ERa_BLA_Antagonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ERa_BLA_Antagonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_FXR_BLA_Antagonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_FXR_BLA_Antagonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_GR_BLA_Antagonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_GR_BLA_Antagonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_PPARd_BLA_Agonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_PPARd_BLA_Antagonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_PPARd_BLA_Antagonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_PPARg_BLA_Antagonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_PPARg_BLA_Antagonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_VDR_BLA_Antagonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_VDR_BLA_Antagonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AR_BLA_Antagonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_AR_BLA_Antagonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p2_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p2_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p2_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_p53_BLA_p2_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_p53_BLA_p3_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p3_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p3_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_p53_BLA_p3_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_p53_BLA_p4_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p4_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p4_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_p53_BLA_p4_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_p53_BLA_p5_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p5_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_p53_BLA_p5_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_p53_BLA_p5_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_VDR_BLA_Agonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_ESRE_BLA_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ESRE_BLA_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_ESRE_BLA_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_ESRE_BLA_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_NFkB_BLA_agonist_ch1 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_NFkB_BLA_agonist_ch2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
background measurement |
TOX21_NFkB_BLA_agonist_ratio |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
dna binding |
TOX21_NFkB_BLA_agonist_viability |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell cycle |
TOX21_MMP_ratio_up |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
cell morphology |
TOX21_AR_LUC_MDAKB2_Antagonist2 |
INACTIVE |
0.00 |
0.00 |
1.00 |
0.00 |
- |
Applicant's summary and conclusion
- Conclusions:
- No active results found for Methanesulfonic acid.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.