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Administrative data

Key value for chemical safety assessment

Effects on fertility

Description of key information

No data are available for for Tetraethylhexyl titanate itself. Rapid hydrolyses into 2 -Ethyl hexanol and Titanium dioxide is expected after ingestion into the body.

2-Ethyl hexanol is rapidly and extensively absorbed via the gastrointestinal tract in rats and rabbit.

2 -Ethylhexanol was evaluated in OECD SID Programme in 1995. Only short summary of the conclusions and reccomendations is available:

Fertility studies are not available, however several oral subacute studies in rat and mice have produced alterations in testicular weight. This was not observed with rats and mice in 90-day repeat dose studies. Developmental studies are available for rats (oral, dermal, inhalation) and mice (oral). Effects were only observed for rats treated by the oral route and included skeletal malformation and retardation. The NOAELrat,oral = 130 mg/kg, the NOAELrat,inhal =

Justification for classification or non-classification