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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:
The justification document on the read across category approach is included in IUCLID 13.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzenesulfonic acid, methyl-, C20-24 (even numbered) sec-alkyl derivs.
EC Number:
939-185-6
Molecular formula:
C8H11(CH2)nSO3 n=19-23
IUPAC Name:
Benzenesulfonic acid, methyl-, C20-24 (even numbered) sec-alkyl derivs.
Test material form:
liquid: viscous
Details on test material:
Appearance: viscous opaque suspension

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
24/48/72 h
Score:
5.33
Max. score:
8
Reversibility:
not fully reversible within: 14 days
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: mean of 1, 24, 48, 72 hrs
Score:
5.25
Max. score:
6
Reversibility:
not reversible
Remarks on result:
other: highly irritating

Applicant's summary and conclusion

Interpretation of results:
Category 1C (corrosive) based on GHS criteria
Conclusions:
No skin irritation/corrosion study with the target substance is available. Data generated with the category substance LABS is considered pivotal to this endpoint and this is the most conservative approach. LABS is classified as category 1C according to CLP regulation (corrosive to skin) and therefore the target substance will also be classified as category 1C. .