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Diss Factsheets
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EC number: 606-172-9 | CAS number: 1893-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The ready biodegradability of Pipamperone was estimated by using BIOWIN, Toxtree and
Vega predictors.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Ready biodegradability predictions.
BIOWIN (EPISuite) |
Toxtree |
Vega |
WoE prediction |
NOT READY BIODEGRADABLE (Moderate reliable) |
PERSISTENT (na*) |
NOT READY BIODEGRADABLE (Not reliable) |
NOT READY BIODEGRADABLE (Moderate reliable) |
BIOWIN models consistently predictedPipamperone as not readily biodegradable. Considering that i) BIOWIN models have an overall good prediction accuracy, ii) Pipamperone is included in the MW range of the training sets of BIOWIN models (MW=375.48), and iii) Pipamperone has structural features represented in the training set of BIOWIN models (i.e., Amide [-C(=O)-N or -C(=S)-N], Carbon with 4 single bonds & no hydrogens, Ketone [-C-C(=O)-C-], Tertiary amine, Fluorine [-F], Aromatic-H, -CH2- [linear], -CH2- [cyclic]), the ready biodegradability prediction provided by BIOWIN was assessed as moderate reliable.
Toxtree assigned Pipamperone to the classpersistent chemical, because the two or more rings structural alerts associated to persistent chemicals was identified. Toxtree prediction was not supported by a detailed reliability evaluation.
Vega predicted the target compound Pipamperone as not ready biodegradable, however the prediction was assessed as not reliable based on the applicability domain index (ADI = 0) and the following issues: i) only moderately similar compounds with known experimental value are included in the training set; ii) similar molecules found in the training set have experimental values that disagree with the predicted value; iii) a prominent number of atom centered fragments of the compound have not been found in the compounds of the training set or are rare fragments.
The target compound Pipamperone was predicted as not ready biodegradable by BIOWIN (moderate reliable prediction), as not ready biodegradable by Vega (not reliable prediction), and as not ready biodegradable by Toxtree (reliability assessment not applicable).
Thus, based on BIOWIN and Toxtree predictions, it was concluded that Pipamperone was predicted as NOT ready biodegradable and the prediction was assessed as moderate reliable.
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