Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 August 2008 - 09 October 2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Test performed in accordance with OECD guidelines.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2008
Report Date:
2008

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
Substance type: white powder
- Physical state: solid
- Analytical purity: 99.80%
- Expiration date of the lot/batch: 31 Jan 2009
- Storage condition of test material: At room temperature in the dark

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
2.2 - 3.1
Temp.:
25 °C
pH:
7
Type:
log Pow
Partition coefficient:
3.6
Temp.:
25 °C
pH:
2.5

Applicant's summary and conclusion

Conclusions:
The Powand log Powvalue of the test substance:
Nuetral pH:
Pow: 1.6*102- 1.4*103
log Pow: 2.2 -3.1

Ph 2.5:
Pow: 3.8*103
log Pow: 3.6
Executive summary:

The results of the Rekker claculation method and the HPLC method differ more than 0.3 log units. Since the HPLC method is a more accurate method, the results of this method are reported.

The Powand log Powvalue of the test substance:

Nuetral pH:

Pow: 1.6*102- 1.4*103

log Pow: 2.2 -3.1

Ph 2.5:

Pow: 3.8*103

log Pow: 3.6