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EC number: - | CAS number: -
A study was performed to assess the acute inhalation toxicity of the test item. The method used was designed to be compatible with that described in the OECD Guidelines for Testing of Chemicals (2009) No. 403 "Acute Inhalation Toxicity" and with Method B2 (Inhalation) of Commission Regulation (EC) No. 440/2008.
A group of ten RccHan™ : WIST strain rats (five males and five females) was exposed to an aerosol atmosphere. The animals were exposed for four hours using a nose only exposure system, followed by a fourteen day observation period.
The mean achieved atmosphere concentration was as follows:
Mean Achieved (mg/L) 5.64
Standard Deviation 0.71
Nominal (mg/L) 18.5
The characteristics of the achieved atmosphere were as follows:
Mean Achieved Atmosphere Concentration (mg/L) 5.64
Mean Mass Median Aerodynamic Diameter (µM) 2.47
Inhalable Fraction (% < 4 µM) 77.2
Geometric Standard Deviation 1.92
No deaths occured. Common abnormalities noted during the study included increased respiratory rate, hunched posture, pilo-erection and wet fur. From Days 5 to 7 post-exposure the animals recovered and all animals in the study appeared normal after day 7 post-exposure.
All males and four female animals exhibited bodyweight losses on the first day post-exposure. All male animals subsequently exhibited reasonable bodyweight gains throughout the remainder of the recovery period. In contrast, three female animals exhibited slight bodyweight losses or showed no bodyweight gain from Days 1 to 3 postexposure. Reasonable bodyweight development was noted in all female animals during the remainder of the recovery period.
With the exception of one instance of dark patches on the lungs, no macroscopic abnormalities were detected amongst animals at necropsy.
No deaths occurred in a group of ten rats exposed to a mean achieved atmosphere concentration of 5.64 mg/L for four hours. It was therefore considered that the acute inhalation median lethal concentration (4 hr LC50) of Complexation products of sodium tartrate with iron trichloride, in the RccHan™ : WIST strain rat, was greater than 5.64 mg/L.
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