Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reason / purpose for cross-reference:
read-across source
Key result
Parameter:
SI
Value:
0.9
Test group / Remarks:
5%
Key result
Parameter:
SI
Value:
1.2
Test group / Remarks:
10%
Key result
Parameter:
SI
Value:
1.2
Test group / Remarks:
25%
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the low stimulation indices observed in the local lymph node assay, WS405777 is considered not to be a skin sensitizer and does not warrant any classification regarding skin sensitisation according to European classification rules [Regulation (EC) 1272/2008].

The same conclusion of non-classification for skin sensitising properties can be drawn for the read-across target substance WS406663 based on the close chemical similarity between the two substances (see IUCLID Section 13 „Validity Assessment Report“ for the read-across approach).