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Ecotoxicological information

Toxicity to microorganisms

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Description of key information

16 h EC10 = 22 mg/L, 16 h EC50 = 38 mg/L (Pseudomonas putida) DIN 38412, part 8, static, no data on GLP, RL2; read-across: N-[3-(dimethylamino)propyl] amides, C8-18 even numbered

Key value for chemical safety assessment

EC50 for microorganisms:
22 mg/L
EC10 or NOEC for microorganisms:
38 mg/L

Additional information

For the assessment of the toxicity of Amides, C8-18, C18 unsatd, N-[3-(dimethylamino)propyl] to microorganisms a study conducted with the closely related source substance Amides, C8-18 even numbered, N-[3-(dimethylamino)propyl] is available.

Supporting data on the target substance itself is also available. The study, however, is insufficiently documented. A justification for read-across is given in IUCLID section 13.


In a 16 hour toxicity study, the cultures of Pseudomonas putida were exposed to Amides, C8-18 even numbered, N-[3-(dimethylamino)propyl] at nominal concentrations of 0, 20, 30, 40, 45, 50, 55, 60, 70, 80 mg/L under static conditions in accordance with the DIN 38412, part 8. The EC10 and EC50 values based on growth inhibition were 22 and 38 mg/L, respectively.  The % growth inhibition in the treated algal culture as compared to the control ranged from 15 to 99. 


In a supporting study according to DIN 38412 (Part 8) conducted with the target substance Amides, C8-18, C18 unsatd, N-[3-(dimethylamino)propyl], the EC10 to Pseudomonas putida of the test substance was determined to be 280 mg/L.