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EC number: 202-442-1 | CAS number: 95-70-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
- Biodegradation
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975-08-01 to 1975-10-07
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Huntingdon study, conducted in 1975, non GLP, report without many details, therefore considered as reliable with restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Remarks:
- study conducted in 1975
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- toluene-2,5-diamine
- IUPAC Name:
- toluene-2,5-diamine
- Details on test material:
- - Name of test material (as cited in study report): toluene-2,5-diamine
- Other: no further details given
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CFY
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: no data- Age at study initiation: no data- Weight at study initiation: 98 - 120 g- Fasting period before study: starved overnight before treatment- Housing: grouping of 5 animals per sex per dose- Diet (e.g. ad libitum): no data- Water (e.g. ad libitum): no data- Acclimation period: no dataENVIRONMENTAL CONDITIONS- Temperature (°C): no data- Humidity (%): no data- Air changes (per hr): no data - Photoperiod (hrs dark / hrs light): no dataIN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aquous solution of sodium sulphite (0.05%)
- Details on oral exposure:
- VEHICLE- Concentration in vehicle: 10% solution- Amount of vehicle (if gavage): 2.5 mL- Justification for choice of vehicle: no justification given- Lot/batch no. (if required): no data- Purity: no dataMAXIMUM DOSE VOLUME APPLIED: 2.5 mL
- Doses:
- 0, 64, 100, 160, and 250 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days - Frequency of observations and weighing: According to the original study report, "during the observation period of 14 days, a record was kept on all mortalities and signs of toxicity".- Necropsy of survivors performed: yes- Other examinations performed: clinical signs, body weight (gain)
- Statistics:
- 95% confidence limits were calculated by the method of Weil C.S. (1952)
Results and discussion
- Preliminary study:
- The results of preliminary range finding tests indicated that the median lethal oral dose (LD50) was in the region of 64 to 250 mg/kg bw.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 102 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 69 - 152
- Mortality:
- Males:0 mg/kg bw: 0 deaths / 5 test animals64 mg/kg bw: 3/5100 mg/kg bw: 4/5160 mg/kg bw: 0/5250 mg/kg bw: 5/5Females:0 mg/kg bw: 0 deaths / 5 test animals64 mg/kg bw: 0/5100 mg/kg bw: 3/5160 mg/kg bw: 5/5250 mg/kg bw: 4/5Deaths occured from 1 hour to 22 hours of treatment.
- Clinical signs:
- other: Lethargy, pilo erection, apraxia and increased salivation. Increase respiratory rate in rats treated at 100 mg/kg bw, and decreased respiratory rate in rats treated above 100 mg/kg bw.
- Gross pathology:
- Autopsy of dead animals revealed slight haemorrhage of lungs, pallor of the spleen, darkening of the liver, and injection of peritoneal blood vessels. for survivors after recovery, the terminal autopsy findings were normal.
- Other findings:
- none reported
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated informationCriteria used for interpretation of results: OECD GHS
- Conclusions:
- With a LD50 = 102 mg/kg bw, test item toluene-2,5-diamine shall be classified as oral acute toxic category 3, (toxic if swallowed, H301) according to the GHS/CLP classification system.
- Executive summary:
The purpose of this study was to evaluate the acute oral toxicity of test item toluene-2,5 -diamine. The study was conducted in 1975 under non GLP conditions, without many details on the methodology given in the study report. Still the procedure as described in the study report obviously was similar to the protocol as given by OECD Guideline 401, thus the study is considered as reliable.
With a LD50 = 102 mg/kg bw, test item toluene-2,5-diamine shall be classified as oral acute toxic category 3, (toxic if swallowed, H301) according to the GHS/CLP classification system. Within the former DSD classification system the classification as T; R25 (toxic if swallowed) applies. Both classifications are in line with the harmonised classification already given for the test item (Annex VI of CLP regulation, Index # 612 -125 -00 -3).
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