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EC number: 202-442-1 | CAS number: 95-70-5
Contact allergy to toluene-2,5-diamine in patch tested dermatitis patients who were, or had been hairdresser. Test substance: toluene-2,5-diamine (TDA) or toluene-2,5-diamine sulphate (TDAs) 1% in petrolatum
(a) hairdresser dermatitis patients with dermatitis from hair cosmetics
Results from several diagnostic patch studies in dermatitis patients and non patient show a high rate of contact allergy to toluene-2,5-diamine and toluene-2,5-diamine sulphate. The results were conducted in several European countries between 1970 and 2002 and involved a total of 20954 patients, which were or had been hairdresser, or hairdresser trainee or hairdresser's client or patient with contact allergy to cosmetic ingredients.
The highest rate was found in dermatitis patients being hairdressers (16.8%), followed by dermatitis patients selected due to symptoms or exposure related to cosmetics (9.5%), and unselected dermatitis patients (2.4%). The rate of contact allergy to toluene-2,5-diamine sulphate in hairdressers (not patients) was 2-2.7%.
Due to different selection criteria and different patch test substances used, conclusions cannot be drawn concerning the trend over time of contact allergy to toluene-2,5-diamine and toluene-2,5-diamine sulphate.
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