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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of the substance to aquatic invertebrates was investigated in 3 studies. In a 48 h acute toxicity study (classified as reliable without restrictions), Daphnia magna were exposed to the substance according to OECD 202 and GLP principles. The 48h-EC50 was 234 mg/L, corresponding to 90 mg solids/L, based on analytically confirmed nominal concentrations. In a 48 h acute toxicity study (classified as reliable with restrictions), Daphnia magna were exposed to the substance according to EU method C.2 and GLP principles. There was no significant effect on daphnia magna mobility observed at the concentration tested (105.8 mg/L, corresponding to 40.6 mg solids/L), based on nominal concentrations (no analytical verification of test concentration). In a 48 h acute toxicity study, of which the reliability could not be assigned, Daphnia magna were exposed to the substance using a method equivalent/similar to OECD 202 but not under GLP principles. The 48h-EC50 was 18 mg/L, corresponding to 7 mg solids/L, based on nominal concentrations (no analytical verification of test concentration).
The EC50 value obtained in the study classified as reliable without restrictions is taken as key value for CSA since it was considered the most reliable.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 234 mg/L
Additional information
The acute toxicity of the substance to aquatic invertebrates was investigated in 3 studies:
Tobor-Kapłon (2013) - In a 48 h acute toxicity study, Daphnia magna were exposed to the substance according to OECD guideline Nr. 202 and GLP principles. Daphnids were exposed to the following nominal concentrations: 0 (control), 7.0, 17, 41, 104 and 259 mg/L, corresponding to 2.7, 6.6, 16, 40 and 100 mg solids/L. The substance did not induce acute immobilisation in Daphnia magna at an analytically confirmed nominal concentration of 104 mg/L, corresponding to 40 mg solids/L, after 48 hours of exposure. The 48h-EC50 was 234 mg/L, corresponding to 90 mg solids/L, based on analytically confirmed nominal concentrations (95% confidence interval between 199 and 306 mg/L, corresponding to 77 and 118 mg solids/L). The present toxicity study is classified as reliable without restrictions.
Bazin et al. (1994) - In a 48 h acute toxicity study, Daphnia magna were exposed to the substance according to EU method C.2 and GLP principles. Daphnids were exposed to the following nominal concentrations: 0 (control) and 105.8 mg/L, corresponding to 40.6 mg solids/L. There was no significant effect on Daphnia magna mobility at the test concentration, based on nominal concentrations (no analytical verification of test concentrations). The present toxicity study is classified as reliable with restrictions.
Romstad and Källqvist (1992) – In a 48 h acute toxicity study, Daphnia magna were exposed to the substance using a method equivalent/similar to OECD guideline Nr. 202 but not under GLP principles. Daphnids were exposed to the following nominal concentrations: 0 (control) 10, 18, 32, 56 and 100 mg/L, corresponding to 3.9, 6.9, 12, 22 and 39 mg solids/L. The 48h-EC50 was 18 mg/L, corresponding to 7 mg solids/L, based on nominal concentrations. The reliability of the study could not be assigned since there was no analytical verification of the test concentrations and important study design details and results are missing in the report (the validity criteria could not be verified).
Selection of key study
The study conducted by Tobor-Kapłon (2013) was selected as the key study since it was considered the most reliable. In the study conducted by Bazin et al. (1994) no analytical measurement of test concentrations was performed. The Romstad and Källqvist (1992) study was not performed under GLP, no analytical verification of the test concentrations was performed, study design details and details on the results are missing in the report (none of the validity criteria can be verified due to the lack of data in the report).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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