Reaction productReaction product of 1,1´-Methylenebis(4-substituted cyclohexane), [2-(substitutedmethyl)-3-prop-2-enoyloxy-2-(prop-2-enoyloxymethyl)propyl] prop-2-enoate and [3-prop-2-substituted-2,2-bis(prop-2-enoyloxymethyl)propyl] prop-2-enoate

Endpoint summary

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (sensitising)

Additional information:

The SI values calculated for the substance concentrations 1, 2.5 and 5% were 11.4, 18.5 and 24.7 respectively. These results show that the test substance elicits an SI ≥ 3. The EC3 value (the estimated test substance concentration that will give a SI =3) was established to be between 0 and 1%. Based on these results: - according to the recommendations made in the test guidelines, Reaction products of 1,1’-methylenebis(4-isocyanatocyclohexane) and pentaerythritol triacrylate and pentaerythritol tetraacrylate would be regarded as skin sensitizer. - according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2011), Reaction products of 1,1’-methylenebis(4-isocyanatocyclohexane) and pentaerythritol triacrylate and pentaerythritol tetraacrylate should be classified as strong skin sensitizer (Category 1, Sub-category 1A). - according to the Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures, Reaction products of 1,1’-methylenebis(4-isocyanatocyclohexane) and pentaerythritol triacrylate and pentaerythritol tetraacrylate should be classified as skin sensitizer (Category 1) and labeled as H317: May cause an allergic skin reaction.

Migrated from Short description of key information:
In an OECD TG 429 study, this substance would be regarded as skin sensitizer.

Justification for classification or non-classification

Please see above "Discussion".