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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25-Mar-2015 to 29-Sep-2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 1
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Qualifier:
according to
Guideline:
OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
GLP compliance:
yes (incl. certificate)
Remarks:
Staatliches Gewerbeaufsichtsamt Hildeshelm
Type of method:
other: Slow-Stirring
Partition coefficient type:
octanol-water
Test material information:
Composition 1
Key result
Type:
log Pow
Partition coefficient:
4.65
Temp.:
25 °C
pH:
5.9

Results

 

Table of results

 

Replicate number

Test duration (h)

Measured concentration

Pow

Log Pow

in

n-octanol (mg/L)

in Aq. phase (mg/L)

Single

Mean

SD +/-

CV

1

90.08

18442

0.419

43993

4.64

4.65

0.02

0.40

95.08

17416

0.404

43088

4.63

114.08

19546

0.411

47509

4.68

119.08

18926

0.416

45473

4.66

2

90.08

17700

0.421

42043

4.62

4.65

0.02

0.39

95.08

18152

0.402

45109

4.65

114.08

19544

0.421

46423

4.67

119.08

18394

0.409

44973

4.65

3

90.08

17232

0.427

40337

4.61

4.64

0.03

0.54

 

95.08

18498

0.414

44724

4.65

 

114.08

18896

0.411

45931

4.66

 

119.08

18782

0.418

44976

4.65

 

Log Pow, Av = 4.649

σ Log Pow, Av = 0.001

 

aq. phase = Aqueous phase

Pow = Partition coefficient (n-octanol / water)

Log Pow = Decadic logarithm of the partition coefficient (n-octanol / water)

SD = Standard Deviation

CV = Coefficient of variation (%)

Log Pow, Av = Weighted average value of log Pow

σLog Pow, Av = Weighted standard deviation

Conclusions

The partition coefficient (n-octanol/water) (log POW) of the test substance was determined at a test temperature of 25 ±1 °C and at a pH value of 5.9 from three independent replicates (test vessels) with four sub-replicates (samples) to be 4.649 ±0.001.

Conclusions:
A log Pow of 4.65 (at 25 °C, pH 5.9) was determined for the test substance according to OECD Guideline 123.

Description of key information

Log Pow: 4.65 at 25 °C, pH 5.9 (OECD Guideline 123, slow stirring)

Key value for chemical safety assessment

Log Kow (Log Pow):
4.65
at the temperature of:
25 °C

Additional information

A log Pow value of 4.65 (at 25 °C, pH 5.9) was determined for the tet substance according to OECD Guideline 123.