Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study has been presented to ECHA in the framework of a NONS notification. The document is now public because presented more than 12 years ago. The summary received is from migrated NONS dossier

Data source

Reference
Reference Type:
other: body responsible for the test
Title:
Unnamed
Year:
1988

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: prepared with 0.9% NaCl solution in a ratio of 1g + 0.7 ml
Duration of exposure:
24h
No. of animals per sex per dose:
5 males and 5 females

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Body weight:
no substance exposure related effects
Gross pathology:
The macroscopically determined findings among the animals killed at the end of the test revealed red discoloration of remaining animals were free from macroscopically visible peculiarities.
Other findings:
The visible areas of skin of some animals were discoloured red during the first week of testing. In addition, isolated cases of small wounds with scabs occurred in the region of the shorn area of skin in the female animals.The findings were reversible 9 days p.a.The remaining animals were free from macroscopically visible peculiarities

Applicant's summary and conclusion

Interpretation of results:
other: not classified under Regulation 1272/2008
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
The substance was tested for acute dermal toxicity following OECD 402. Under the experimental conditions the LD50 > 2000 mg/kg bw.
Executive summary:

The substance was tested for acute dermal toxicity following OECD 402. Under the experimental conditions the LD50 > 2000 mg/kg bw.