Registration Dossier
Registration Dossier
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EC number: 941-637-2 | CAS number: 1384257-92-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute oral toxicity of selected flavor chemicals
- Author:
- Moran E.J., Easterday O.D.
- Year:
- 1 980
- Bibliographic source:
- Drug and Chemical Toxicology, 3, 249-258
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- no information on necropsy provided
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl cyclohexanecarboxylate
- EC Number:
- 221-945-7
- EC Name:
- Ethyl cyclohexanecarboxylate
- Cas Number:
- 3289-28-9
- Molecular formula:
- C9H16O2
- IUPAC Name:
- ethyl cyclohexanecarboxylate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: FDLR strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Waverly, New York
- Age at study initiation: not specified
- Weight at study initiation: 40 to 60 g
- Fasting period before study: overnight
- Diet: ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- not specified
- Doses:
- not specified
- No. of animals per sex per dose:
- 5 (five)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily for 14 days
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs - Statistics:
- yes, but not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 962 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 3 002 - < 5 230
- Mortality:
- yes
- Clinical signs:
- not provided
- Body weight:
- not provided
- Gross pathology:
- not performed
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- Cyclohexanecarboxylic acid ethyl ester was investigated for acute oral toxicity in the rat and a LD50 value of 3962 mg/kg bw was established.
- Executive summary:
Cyclohexanecarboxylic acid ethyl ester was investigated for acute oral toxicity in the rat and a LD50 value of 3962 mg/kg bw was established.
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