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Physical & Chemical properties

Partition coefficient

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Determination of the Partition Coefficient (n-Octanol/Water) of 
FAT 40853/A TE
by High Performance Liquid
Chromatography (HPLC)
(GLP compliant study based on OECD Guideline for Testing of Chemicals, Guideline No. 117: ”Partition coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) method”, adopted April 13, 2004 and Commission Regulation (EC) No 440/2008, Annex, Part A, Methods for the determination of physico-chemical properties, A.8 ”Partition coefficient” and Product Properties Test Guideline OPPTS 830.7570 of the United States Environment Protection Agency (EPA), August 1996)
Author: Gundula Mollandin
Study Completion Date: January 23, 2012

Key value for chemical safety assessment

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The partition coefficient of the test item was to be determined from its retention time on a RP 18 column in comparison with recommended reference items. No retention was found for the test item under two different test conditions.

Therefore the logarithmic partition coefficient (n-octanol/water) of the test item was estimated to be below 0.3 (lowest available reference value) using the HPLC method.