Registration Dossier
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EC number: 251-752-3 | CAS number: 33941-99-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26-Nov 2015 to 04-Dec-2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Staatliches Gewerbeaufsichtsamt Hildeshelm
- Type of method:
- flask method
- Key result
- Water solubility:
- 2.57 g/L
- Temp.:
- 20 °C
- pH:
- 4
- Conclusions:
- A water solubility value of 2.57 g/L (at 20 °C, pH 4.0) was determined for the test substance according to E.U. Method A.6.
Reference
Results
Preliminary Test (non GLP)
The determined solubility in double distilled water was in the range of 2.016 - 4.032 g/L. For the application dose for the definitive study, approx. 20 g/L was used (approximately five times the maximum solubility result).
Main test
Water solubility results at 20 °C
Pre-incubation time |
Replicate No. |
Concentration1) (g/L) |
Mean |
24 h |
1 |
2.56 |
2.54 |
2 |
2.51 |
||
48 h |
1 |
2.58 |
2.59 |
2 |
2.60 |
||
72 h |
1 |
2.56 |
2.57 |
2 |
2.58 |
||
Mean (24 – 72 h) |
SD |
2.57 |
|
Deviation (%) (24 – 72)2) |
CV (%) |
2.0 |
1) Mean value of double injections, dilution factor of 200 and exact weighs taken into account
2) Calculated according to the formula:
Deviation (%) = 100 x (max value - min value) / min value
SD Standard deviation
CV Coefficient of variation
No significant signal was determined for the control sample.
Validity Criteria
The study was performed based on OECD Guideline 105 for Testing of Chemicals (1995) and Council Regulation (EC) No. 260/2014, Method A.6. The validity criteria were fulfilled:
- The concentration measured did not differ by more than 15 %.
- Temperatures were kept constant within ± 0.5 °C.
Description of key information
Water solubility: 2.57 g/L at 20 °C, pH =4.0 (EU Method A.6., flask method)
Key value for chemical safety assessment
- Water solubility:
- 2.57 g/L
- at the temperature of:
- 20 °C
Additional information
A water solubility value of 2.57 g/L (at 20 °C, pH 4.0) was determined for the test substance according to E.U. Method A.6.
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