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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
04-Nov-2015 to 02-Dec-2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
yes (incl. certificate)
Remarks:
Staatliches Gewerbeaufsichtsamt Hildeshelm
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Key result
Type:
log Pow
Partition coefficient:
2.19
Temp.:
24.7 °C
Remarks on result:
other: Temperature of HPLC column. No pH value provided.

Results of Test Item Analysis

The table contains the retention time data and calculated log k values of the test item. Two individual log Pow values were derived under consideration of the first and second calibration. Finally, a mean value was calculated from these individual log Pow values.

Retention Times, Capacity Factors and Partition Coefficients

tR(min)

k

log k

log Pow

 

1st calibration

2nd calibration

5.375

8.41

0.925

2.19 +/- 0.05

2.05 to 2.32

(95 % CI)

2.18 +/- 0.05

2.05 to 2.31

(95 % CI)

5.377

8.42

0.925

Mean

5.376

8.42

0.925

2.19

 

 tR: Retention time

k: Capacity factor test item

Pow : Partition Coefficient (n-octanol / water)

CI : Confidence Interval

Conclusions

Two individual log Kow values for the test item were derived under consideration of the first and second calibration. Finally, a mean value was calculated from these individual log Pow values to be 2.19.

Conclusions:
A log Pow of 2.19 (at 24.7 °C) was determined for the test substance according to EU Method A.8.

Description of key information

Log Pow: 2.19 at 24.7 °C (EU Method A.8., HPLC method)

Key value for chemical safety assessment

Log Kow (Log Pow):
2.19
at the temperature of:
24.7 °C

Additional information

A log Pow of 2.19 (at 24.7 °C) was determined for the test substance according to EU Method A.8.