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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Radiolabelling:
- no
- Test temperature:
- 25 °C (column temperature)
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus:
- Type: Agilent 1200 Series Liquid Chromatograph
- Type, material and dimension of analytical (guard) column: HyperClone 5µ CN (CPS) (25 cm x 4.6 mm internal diameter)
- Detection system: UV set at 210 nm
MOBILE PHASES
- Type: methanol:water (55:45 v/v)
- Experiments with additives carried out on separate columns: no additives used
- pH: no data
- Solutes for dissolving test substance: methanol (filtrate (0.45 µm, PTFE) of a saturated solution of the test substance in methanol, prepared by mixing the test substance with this solvent for 7 days at 20˚C. Dissolution of the test substance is poor in water-miscible solvents)
- Solutes for dissolving reference substances: HPLC mobile phase
DETERMINATION OF DEAD TIME
- Method: by inert substance which is not retained by the column (formamide)
REFERENCE SUBSTANCES
- Identity: Acetanilide, Nitrobenzene, Naphthalene, 2-Methylnaphthalene, Anthracene, DDT
- Known logKoc values: 1.3, 2.4, 2.8, 3.9, 4.4, 5.6
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: not applicable, since the filtrate of a saturated solution of the test substance in methanol was used
- Quantity of reference substances:
Formamide (internal deadtime standard): 4.0 µg, Acetanilide: 0.2 µg, Nitrobenzene: 0.2 µg, Naphthalene: 0.05 µg, 2-Methylnaphthalene: 0.05 µg, Anthracene: 0.2 µg, DDT: 0.2 µg
EVALUATION
- Qualitative comparison of chromatograms obtained for the test and reference substances. - Key result
- Type:
- log Koc
- Value:
- > 5.6
- Temp.:
- 25 °C
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: acetanilide (3.6 min), nitrobenzene (4.3), naphthalene (5.3), 2-methylnaphthalene (6.0), anthracene (8.3), DDT (14.9)
- Average retention data for test substance: There were no significant peaks present in the test substance chromatogram before the retention time of DDT, the highest available reference standard with a known log10Koc value of 5.6.
It was thus considered either that the method was inapplicable due to the components of the test substance being too insoluble for detection, or that any soluble components of the test substance eluted after DDT (or did not elute under the conditions of the analysis).
As confirmation, computer modelling (KOCWIN, Version 2.00, U.S. Environmental Protection Agency) was used and indicated log10Koc values between 7 and 8 for representative constituents of the test substance. - Validity criteria fulfilled:
- not applicable
Reference
Description of key information
Log Koc at 25 °C: >5.6 (HPLC method; OECD 121, EU C.19)
Key value for chemical safety assessment
Additional information
The main components of the test material were found to have LogKoc values greater than 5.6
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