Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 600-299-3 | CAS number: 102322-83-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Mar 2016 to 14 Apr 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss Federal Office for the Environment
- Type of method:
- flask method
- Key result
- Water solubility:
- 3 018 mg/L
- Temp.:
- 20 °C
- pH:
- 3.8
- Conclusions:
- During this study, the water solubility of the test was determined at 20°C at a mean pH value of 3.8 using the shake flask method. The water solubility was found to be 3018 mg/L ± 25 mg/L according to OECD 105.
Reference
Results
The tabulated values (see Table 1) represent rounded results, obtained by calculation using the exact raw data. Based on the chromatographic data, the test item was considered to be stable during the test.
Table 1: Results of the Water Solubility of the test item
Sample No. |
Shaking time at 30°C [hours] |
Measured concentration [mg/L] |
Water Solubility Mean Value [mg/L] |
Overall Mean ± Std. Dev. [mg/L] |
Rel. Std. Dev. [%] |
1 2 |
72 72 |
3051 3043 |
3047 |
3018 ± 25 |
± 0.8% |
3 4 |
48 48 |
2986 3019 |
3003 |
||
5 6 |
24 24 |
2966 3043 |
3005 |
According to the test guideline, the repeatability of the three assays should be < 15 %. The relative standard deviation was found to be 0.8 %. Thus, the acceptance criterium was fulfilled and the saturation was achieved after 24 hours. Therefore, the study is valid. The R² fit of the calibration curve used was 0.9996. This reflects the linearity of the analytical system within the calibration range of 4.68 – 30.9 mg test item/L.
Description of key information
The water solubility of the test was determined at 20°C at a mean pH value of 3.8 using the shake flask method. The water solubility was found to be 3018 mg/L ± 25 mg/L according to OECD 105.
Key value for chemical safety assessment
- Water solubility:
- 3 018 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
