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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
Justification for type of information:
QSAR Prediction

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2016

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
2.94 mg/L
Nominal / measured:
estimated
Remarks on result:
other: Database: Aquatic OASIS
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
2.45 mg/L
Nominal / measured:
estimated
Remarks on result:
other: T.E.S.T. HCM
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
4.44 mg/L
Nominal / measured:
estimated
Remarks on result:
other: T.E.S.T. CM

Applicant's summary and conclusion

Conclusions:
According to (Q)SAR modells: QSAR Toolbox, T.E.S.T., the predicted values indicated that tolperisone is hazardous to the fishes. The result meets the requirement of Aquatic Acute Category 2.