Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

oral

rat (OECD 409)  NOAEL (m/f): 55 mg/kg bw/day  (BASF AG, 1988)

dermal

Actually, there is no information available.

inhalation

Actually, there is no information available.

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
NOAEL
55 mg/kg bw/day
Study duration:
subacute
Species:
rat

Additional information

Justification for classification or non-classification

Based on the GHS and the EU criteria for classification and labelling, according to the above mentioned 28 -day subacute study the concentration/uptake (C) range for classification of toxic effects is 30<C<300 mg/kg bw/day. Substance-related toxic effects were observed at 645 mg/kg bw/day mean uptake of test substance (range 489 -736 mg/kg bw/day). Therefore there is currently no need for classification of effects due to repeated oral exposure to the test substance. There are no data available given to classify the test substance for repeated dermal or inhalative toxicity.