Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 June 2011- 12 December 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 5.6 - 5.7
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not measured
- Details on results:
- A calibration plot of log10k versus log10Pow was constructed for the reference standards. The logarithms of the capacity factors for the test substance were then calculated and the log10Pow values were determined by interpolation.
The two main components of LZ1554 were thus determined to have log10Pow values of 5.6 and 5.7 respectively (equivalent Pow values of 4.1 x E5 and 5.6 x E05). - Conclusions:
- The substance LZ1554 was found to have log Pow values ranging from 5.6 to 5.7 at 20 °C.
- Executive summary:
The partition coefficient was determined in a GLP-compliant study according to OECD guideline. no. 117 and EC method A.8, applying the HPLC- method. The substance LZ1554 was found to have log Pow values ranging from 5.6 to 5.7.
Reference
log10Powwasdetermined in duplicate which gave results of 5.6 and 5.7 for both sample sets.
Description of key information
Partition coefficient:
The log Pow values ranged from 5.6 to 5.7 at 25 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.65
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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