Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 211-049-4 | CAS number: 628-68-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre-Guideline and Pre-GLP-Study but sufficiently documented for Risk assessment.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Chemical Burns of the Rabbit Cornea
- Author:
- Charles P. Carpenter, Henry F. Smyth Jr.
- Year:
- 1 946
- Bibliographic source:
- American Journal of Ophthalmology 29, 1363, 1946
- Reference Type:
- secondary source
- Title:
- No data
- Author:
- No data
- Year:
- 2 016
- Bibliographic source:
- RTECS-Database 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Pre-Guideline and Pre-GLP-Study
- GLP compliance:
- no
Test animals / tissue source
- Species:
- rabbit
Results and discussion
In vivo
Results
- Remarks on result:
- other: Old literature or database data. No detailed results available.
Any other information on results incl. tables
On application of 500 mg of the substance into the eye of a rabbit a moderate irritation was observed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
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