Registration Dossier
Registration Dossier
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EC number: 214-590-4 | CAS number: 1156-51-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April - June 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Test Substance Name: LZ 514
- Source: Lonza Ltd, Visp/Switzerland
- Lot/batch No.of test material: 5011
- Expiration date of the lot/batch: 2nd December 2017
- Manufacture date: 3rd December 2015
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage conditions: Controlled room temperature (15-25 ºC, below 70 RH%), protected from light and humidity.
- Stability under test conditions: stable
- Safety precautions: Routine safety precautions (lab coat, gloves, safety glasses, face mask) for unknown materials were applied to assure personnel health and safety. - Key result
- Water solubility:
- 0.944 mg/L
- Conc. based on:
- test mat. (total fraction)
- Loading of aqueous phase:
- 1 000 mg/L
- Incubation duration:
- 24 - 72 h
- Temp.:
- 20 °C
- pH:
- 5.87 - 6.4
- Remarks on result:
- other: mean of 24, 48 and 72h measurements
- Details on results:
- - Measured concentration after 24 hours (mg/L): 0.886
- Measured concentration after 48 hours (mg/L): 0.972
- Measured concentration after 72 hours (mg/L): 0.958 - Conclusions:
- The water solubility was determined to be 0.944 ± 0.033 mg/L (95% confidence interval) at 20°C.
- Executive summary:
The study was conducted according to EC method A.6, using the shake-flask method. In conclusion, the water solubility of LZ 514 was determined to be 0.944 ± 0.033 mg/L (95% confidence interval) at 20°C.
Reference
Description of key information
The study was conducted according to EC method A.6, using the shake-flask method. In conclusion, the water solubility of LZ 514 was determined to be 0.944 ± 0.033 mg/L (95% confidence interval) at 20°C.
Key value for chemical safety assessment
- Water solubility:
- 0.944 mg/L
- at the temperature of:
- 20 °C
Additional information
Source: GLP-report
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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