Registration Dossier
Registration Dossier
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EC number: 406-030-4 | CAS number: 105812-81-5
Guidance on Safe Use
Administrative data
First-aid measures
Fire-fighting measures
Accidental release measures
Handling and storage
It’s used in three steps chemical synthesis only:
- Mesylation reaction using mesyl chloride
- Mesyl group substitution by sesamol,
- salification and salt cristallization using acetic acid or hydrochloric acid
The process is carried on using closed reactors equipped with mechanical seals and valves. The load operation of the raw material (powder) is performed under specific exhaust system by personnel using tivek disposable clothes and mask with powder filter.
Pumps and dedicated pipes, made by compatible material, are used to move liquid or suspension from a reactor to another.
The intermediates are isolated using centrifuge completely sealed and inert zed by nitrogen.
The mother liquors are collected in dedicated tank using closed loop pipes and stored before to be send to the external waste.
There are no emissions in the work places in the normal production condition. The only hypothetical emissions are related with accident scenario.There are not diffuse emission. During the periodic enviroment controls in the work place no presence of the substance was found
The work places and the SOP are compliant with the actual Italian legislation ( D.Lgv 81/2008,D. Lgv 334/99-Seveso ). The production facility is managed through a Safety System (SGS) which is periodically controlled by the authority. All the production equipments (reactors, tanks, filters, driers) are made in the right materials and are managed by a preventive maintenance program.
All the “in pressure“ equipments are periodically verified by the authorities (ARPA, ISPSEL). The work places are periodically verified by the authority and by an external specialist in Labour Medicine and preventively authorized by the Italian Inter Minister (VVFF).
All the production areas are classified following the ATEX regulation and a Fire Prevent Certification (CPI) is available.
The health of the personnel dedicated to the raw material, intermediates and finished products handling is periodically monitored by a Labour Medicine specialist following a preapproved sanitary protocol.
The workers (production, warehouse, laboratories) are informed and trained on the chemical and toxicological characteristics of the substance in use and they are trained on the individual protection devices and safety procedure. The personnel is even trained on the emergency events and first aid.
Updated “ Material Safety Data Sheets “, 16 points European form, are available in the work place.
A complete collection of written SOP related to the GMP and Safety is available in the work places.
Transport information
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
Stability and reactivity
Disposal considerations
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
