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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
specific investigations: other studies
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable well documented publication

Data source

Reference
Reference Type:
publication
Title:
Acute hepatic and renal toxicity of dichlorobenzene isomers in Fischer 344 rats
Author:
Valentovic MA, Ball JG, Anestis D, & Madan E
Year:
1993
Bibliographic source:
Journal of applied Toxicology, Vol.13(1), 1-7

Materials and methods

Principles of method if other than guideline:
Male Fischer 344 rats were injected with 1,3-dichlorobenzene. Hepatic and renal toxicity was quantitated 24 hour after injection of 1,3-dichlorobenzene.
GLP compliance:
not specified
Type of method:
in vivo
Endpoint addressed:
not applicable

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-dichlorobenzene
EC Number:
208-792-1
EC Name:
1,3-dichlorobenzene
Cas Number:
541-73-1
Molecular formula:
C6H4Cl2
IUPAC Name:
1,3-dichlorobenzene

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
corn oil
Duration of treatment / exposure:
24-48 hours
Doses / concentrations
Remarks:
Doses / Concentrations:
2, 3 or 4mmol/kg
Basis:
nominal conc.
No. of animals per sex per dose:
4
Control animals:
other: pair fed control (PFC) animals were injected (i.p) with corn oil

Results and discussion

Details on results:
Liver morphology was relatively normal in rats treated with 1,3-dichlorobenzene. 1,3-dichlorobenzene showed only minimal effects on the kidney.

Any other information on results incl. tables

Liver morphology was relatively normal in rats treated with 1, 3-dichlorobenzene or 1, 4-dichlorobenzene. In contrast to the isomers 1, 2-dichlorobenzene (especially hepatotoxicity) and 1, 4-dichlorobenzene (especially renal toxicity), 1, 3-dichlorobenzene showed only minimal effects on the kidney.

Applicant's summary and conclusion

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