Registration Dossier
Registration Dossier
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EC number: 208-792-1 | CAS number: 541-73-1
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute hepatic and renal toxicity of dichlorobenzene isomers in Fischer 344 rats
- Author:
- Valentovic MA, Ball JG, Anestis D, & Madan E
- Year:
- 1 993
- Bibliographic source:
- Journal of applied Toxicology, Vol.13(1), 1-7
Materials and methods
- Principles of method if other than guideline:
- Male Fischer 344 rats were injected with 1,3-dichlorobenzene. Hepatic and renal toxicity was quantitated 24 hour after injection of 1,3-dichlorobenzene.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- not applicable
Test material
- Reference substance name:
- 1,3-dichlorobenzene
- EC Number:
- 208-792-1
- EC Name:
- 1,3-dichlorobenzene
- Cas Number:
- 541-73-1
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,3-dichlorobenzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- corn oil
- Duration of treatment / exposure:
- 24-48 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2, 3 or 4mmol/kg
Basis:
nominal conc.
- No. of animals per sex per dose:
- 4
- Control animals:
- other: pair fed control (PFC) animals were injected (i.p) with corn oil
Results and discussion
- Details on results:
- Liver morphology was relatively normal in rats treated with 1,3-dichlorobenzene. 1,3-dichlorobenzene showed only minimal effects on the kidney.
Any other information on results incl. tables
Liver morphology was relatively normal in rats treated with 1, 3-dichlorobenzene or 1, 4-dichlorobenzene. In contrast to the isomers 1, 2-dichlorobenzene (especially hepatotoxicity) and 1, 4-dichlorobenzene (especially renal toxicity), 1, 3-dichlorobenzene showed only minimal effects on the kidney.
Applicant's summary and conclusion
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