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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vitro / ex vivo
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Justification for type of information:
Octafluoropropane is a gas, making testing difficult. However, numerous studies have shown that saturated perfluorocarbons as a class as not irritating to skin.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
2011
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report date:
2009
Reference Type:
study report
Title:
Unnamed
Year:
1995
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
EPISKIN(TM) reconstructed human epidermis was treated for a period of 15 minutes, followed by an incubation period of 42 hours. Cell viability was measured colorimetrically by the enzymatic reduction of yellow MTT tetrazolium salt.
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1,1,2,2,3,3,4,5,5,5-undecafluoro-4-(trifluoromethyl)pentane
EC Number:
206-575-6
EC Name:
1,1,1,2,2,3,3,4,5,5,5-undecafluoro-4-(trifluoromethyl)pentane
Cas Number:
355-04-4
Molecular formula:
C6F14
IUPAC Name:
1,1,1,2,2,3,3,4,5,5,5-Undecafluoro-4-(trifluoromethyl)pentane
Test material form:
liquid: volatile

In vitro test system

Test system:
human skin model
Source species:
human
Cell type:
non-transformed keratinocytes
Vehicle:
unchanged (no vehicle)
Control samples:
yes, concurrent negative control
yes, concurrent positive control
Amount/concentration applied:
10 microlitre
Duration of treatment / exposure:
15 minutes
Duration of post-treatment incubation (if applicable):
42 hours
Number of replicates:
3

Results and discussion

In vitro

Results
Irritation / corrosion parameter:
% tissue viability
Run / experiment:
mean
Value:
ca. 91.7
Remarks on result:
no indication of irritation
Other effects / acceptance of results:
The relative mea viability of the test item treated tissues was 91.7% after a 15 minute exposure period. The quality criteria for acceptance of results in the test were satisfied.

Applicant's summary and conclusion

Conclusions:
The test item was considered to be non-irritant. Together with the results from other saturated perfluorocarbons, we can be confident octafluoropropane is not irritating.
Executive summary:

Octafluoropropane is non-irritant.