Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Justification for type of information:
As octafluoropropane is a gas, oral toxicity is not testable. However, acute oral toxicity has been performed on numerous perfluorocarbons, including 12 for which the study reports are attached. The data reported is for perfluorodecalin, as this is the most recent test report that we have.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1996
Report Date:
1996
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report Date:
1960
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report Date:
1967
Reference Type:
study report
Title:
Unnamed
Year:
1968
Report Date:
1968
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report Date:
1989
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report Date:
1982
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report Date:
1989
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report Date:
1987
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report Date:
1969
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report Date:
1985
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report Date:
1983
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report Date:
1983

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Test type:
fixed dose procedure
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
Single 2000 mg/kg dose
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
other: Maximum dose tested to show non-toxic
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
None
Clinical signs:
None
Body weight:
No change
Gross pathology:
No change
Other findings:
None

Applicant's summary and conclusion

Conclusions:
Octafluoropropane has no signidficant acute oral toxicity.
Executive summary:

Octafluoropropane has no signidficant acute oral toxicity.