Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
Ammonium carbonate and ammonium hydrogen carbonate (formerly Amonium bicarbonate)
Author:
WHO
Year:
1982
Bibliographic source:
WHO Food Additives Series 17

Materials and methods

Type of study / information:
monograph
Principles of method if other than guideline:
not applicable

Test material

Constituent 1
Reference substance name:
ammonium carbonate and ammonium hydrogen carbonate (formerly ammonium bicarbonate)
IUPAC Name:
ammonium carbonate and ammonium hydrogen carbonate (formerly ammonium bicarbonate)

Results and discussion

Any other information on results incl. tables

These compounds (ammonium ion and bicarbonate ion) are normal metabolites in man. Although specific toxicological data for ammonium carbonate and ammonium bicarbonate are limited, extrapolation of results from studies with ammonium compounds (primarily ammonium chloride) and with sodium or potassium carbonate provide a basis for evaluation. Clinical studies in man show that administration of high doses of ammonium chloride or of sodium bicarbonate results in changes in the acid-base balance. This is the normal physiological response. The levels of ammonium carbonate and bicarbonate in the diet from food additive use are extremely small compared to the levels required to cause physiological changes and pose no toxicological hazard.

Estimate of acceptable daily intake for man: Not specified.

Applicant's summary and conclusion