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Toxicological information

Carcinogenicity

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Description of key information

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
375 mg/kg bw/day
Study duration:
chronic
Species:
rat

Carcinogenicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Non-neoplastic lesions of the kidney were observed in both dose groups of both sexes of rats and mice.

In addition, an evaluation between the members of ETAD, confirmed that there is no evidence to classify Acid Orange 3 as carcinogenic.


Justification for selection of carcinogenicity via oral route endpoint:
Higher dose

Carcinogenicity: via dermal route (target organ): urogenital: kidneys

Justification for classification or non-classification

Non-neoplastic lesions of the kidney were observed in both dose groups of both sexes of rats and mice.

In addition, an evaluation between the members of ETAD, confirmed that there is no evidence to classify Acid Orange 3 as carcinogenic.