Registration Dossier
Registration Dossier
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EC number: 210-734-5 | CAS number: 622-40-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicological Evaluation of Hydroxyethylmorpholine
- Author:
- Papciak, R.J. and Mallory, V.T.
- Year:
- 1 990
- Bibliographic source:
- Journal of the American College of Toxicity
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Remarks:
- Probably no
Test material
- Reference substance name:
- 2-morpholinoethanol
- EC Number:
- 210-734-5
- EC Name:
- 2-morpholinoethanol
- Cas Number:
- 622-40-2
- Molecular formula:
- C6H13NO2
- IUPAC Name:
- 2-morpholinoethanol
- Reference substance name:
- O(CCN(C1)CCO)C1
- IUPAC Name:
- O(CCN(C1)CCO)C1
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Details on study design:
- Protocol: Test article (0.5 ml) was applied to shaved skin sites (intact and abraded, occluded) of 6 young adult New Zealand White rabbits, weighing 2 to 3 kg. Dermal scoring of erythema and edema on both skin sites at 24 and 72 hours, and calculation of the primary irritation index, was performed according to Draize (1959). Study duration was 4 days.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0.66
- Reversibility:
- fully reversible within: 4 days
- Irritant / corrosive response data:
- Draize Primary Irritation Index = 0.66 of 8.0; considered to be minimally irritating. Slight to well-defined erythema was observed only at the 24 hour observations; very slight edema was observed at the 72 hour observations. All scores returned to normal by the 4 day observations.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Conclusions:
- The intermediate substance is not classified with regards to Skin irritation according to CLP Criteria
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