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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1982
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Acute Toxicological Evaluation of Hydroxyethylmorpholine
Author:
Papciak, R.J. and Mallory, V.T.
Year:
1990
Bibliographic source:
Journal of the American College of Toxicity

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Remarks:
Probably no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-morpholinoethanol
EC Number:
210-734-5
EC Name:
2-morpholinoethanol
Cas Number:
622-40-2
Molecular formula:
C6H13NO2
IUPAC Name:
2-morpholinoethanol

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female

Administration / exposure

Type of coverage:
other: non-occluding dressings
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Protocol: Four exposure groups (6.3, 8.0, 10.0 and 16.0 g/kg, determined by a prescreen) of 4 New Zealand White rabbits (5/sex), weighing 2 to 3 kg, received test article on shaved, intact skin of their backs (about 10 % of total body area), for 24 hours using non-occluding dressings. Study duration was 14 days.
Duration of exposure:
14 days
Doses:
6.3, 8.0, 10.0 and 16.0 g/kg
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: no data

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 16 000 mg/kg bw
Based on:
test mat.
Mortality:
Mortality pattern: 1/10 @ 6.3 g/kg ; 0/10 @ 8.0, 10.0, 16.0 g/kg
Other findings:
Necropsy findings (study death): determined that death was not compound related. terminal necropsy: no visible lesions were observed.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The intermediate substance is not classified with regards to Dermal Acute Toxicity