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Registration Dossier
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EC number: 210-734-5 | CAS number: 622-40-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicological Evaluation of Hydroxyethylmorpholine
- Author:
- Papciak, R.J. and Mallory, V.T.
- Year:
- 1 990
- Bibliographic source:
- Journal of the American College of Toxicity
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Remarks:
- Probably no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-morpholinoethanol
- EC Number:
- 210-734-5
- EC Name:
- 2-morpholinoethanol
- Cas Number:
- 622-40-2
- Molecular formula:
- C6H13NO2
- IUPAC Name:
- 2-morpholinoethanol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- other: non-occluding dressings
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Protocol: Four exposure groups (6.3, 8.0, 10.0 and 16.0 g/kg, determined by a prescreen) of 4 New Zealand White rabbits (5/sex), weighing 2 to 3 kg, received test article on shaved, intact skin of their backs (about 10 % of total body area), for 24 hours using non-occluding dressings. Study duration was 14 days.
- Duration of exposure:
- 14 days
- Doses:
- 6.3, 8.0, 10.0 and 16.0 g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: no data
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 16 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality pattern: 1/10 @ 6.3 g/kg ; 0/10 @ 8.0, 10.0, 16.0 g/kg
- Other findings:
- Necropsy findings (study death): determined that death was not compound related. terminal necropsy: no visible lesions were observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The intermediate substance is not classified with regards to Dermal Acute Toxicity
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