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Registration Dossier
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EC number: 281-064-9 | CAS number: 83846-85-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- In vivo study
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 3/8/1987 to 17/8/1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted to the OECD/EU guidelines in place at the time. It was also subject to QA however not under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-(4-methylphenylthio)benzophenone
- EC Number:
- 281-064-9
- EC Name:
- 4-(4-methylphenylthio)benzophenone
- Cas Number:
- 83846-85-9
- Molecular formula:
- C20H16OS
- IUPAC Name:
- {4-[(4-methylphenyl)sulfanyl]phenyl}(phenyl)methanone
- Test material form:
- solid: crystalline
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Controls:
- no
- Amount / concentration applied:
- 0.1 ml (equivalent to 65mg)
- Duration of treatment / exposure:
- One dose
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- Three males
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 24,48, 72 hrs
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24,48, 72 hrs
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24,48, 72 hrs
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hrs
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24,48, 72 hrs
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: 24,48, 72 hrs
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: 24,48, 72 hrs
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24,48, 72 hrs
- Score:
- 0.7
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 24,48, 72 hrs
- Score:
- 0.7
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hrs
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- other: 24,48, 72 hrs
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- other: 24,48, 72 hrs
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 24,48, 72 hrs
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hrs
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other: 24,48, 72 hrs
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hrs
- Irritant / corrosive response data:
- No effects on the cornea or iris were observed in any animals at any time point. Conjuctival effects (redness and/or chemosis) were seen in all animals however this was fully resolved within 72 hours of dosing.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance was not irritating to the rabbit eye
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