Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
eye irritation, other
Remarks:
In vivo study
Type of information:
experimental study
Adequacy of study:
key study
Study period:
3/8/1987 to 17/8/1987
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was conducted to the OECD/EU guidelines in place at the time. It was also subject to QA however not under GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-(4-methylphenylthio)benzophenone
EC Number:
281-064-9
EC Name:
4-(4-methylphenylthio)benzophenone
Cas Number:
83846-85-9
Molecular formula:
C20H16OS
IUPAC Name:
{4-[(4-methylphenyl)sulfanyl]phenyl}(phenyl)methanone
Test material form:
solid: crystalline

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Controls:
no
Amount / concentration applied:
0.1 ml (equivalent to 65mg)
Duration of treatment / exposure:
One dose
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
Three males

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
animal #1
Time point:
other: 24,48, 72 hrs
Score:
0
Max. score:
0
Irritation parameter:
iris score
Basis:
animal #1
Time point:
other: 24,48, 72 hrs
Score:
0
Max. score:
0
Irritation parameter:
conjunctivae score
Basis:
animal #1
Time point:
other: 24,48, 72 hrs
Score:
0.3
Max. score:
1
Reversibility:
fully reversible within: 48 hrs
Irritation parameter:
chemosis score
Basis:
animal #1
Time point:
other: 24,48, 72 hrs
Score:
0
Max. score:
0
Irritation parameter:
cornea opacity score
Basis:
animal #2
Time point:
other: 24,48, 72 hrs
Score:
0
Max. score:
0
Irritation parameter:
iris score
Basis:
animal #2
Time point:
other: 24,48, 72 hrs
Score:
0
Max. score:
0
Irritation parameter:
conjunctivae score
Basis:
animal #2
Time point:
other: 24,48, 72 hrs
Score:
0.7
Max. score:
2
Reversibility:
fully reversible within: 72 hours
Irritation parameter:
chemosis score
Basis:
animal #2
Time point:
other: 24,48, 72 hrs
Score:
0.7
Max. score:
1
Reversibility:
fully reversible within: 72 hrs
Irritation parameter:
cornea opacity score
Basis:
animal #3
Time point:
other: 24,48, 72 hrs
Score:
0
Max. score:
0
Irritation parameter:
iris score
Basis:
animal #3
Time point:
other: 24,48, 72 hrs
Score:
0
Max. score:
0
Irritation parameter:
conjunctivae score
Basis:
animal #3
Time point:
other: 24,48, 72 hrs
Score:
0.3
Max. score:
1
Reversibility:
fully reversible within: 48 hrs
Irritation parameter:
chemosis score
Basis:
animal #3
Time point:
other: 24,48, 72 hrs
Score:
0.3
Max. score:
1
Reversibility:
fully reversible within: 48 hrs
Irritant / corrosive response data:
No effects on the cornea or iris were observed in any animals at any time point. Conjuctival effects (redness and/or chemosis) were seen in all animals however this was fully resolved within 72 hours of dosing.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The substance was not irritating to the rabbit eye