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Administrative data

Description of key information

LD50, oral, rat, f ca. > 2000 mg/kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
> 2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

For the acute toxicity, analogue substances were tested.


For the acute oral toxicity five females of Wistar at limit dose of ca. 2000 mg/kg bw were dosed Under the experimental conditions the LD50, f, > 2000 mg/kg bw. No mortality or signs of toxicity were observed.


 


No deaths or clinical signs related to substance exposure were recorded for the acute dermal toxicity test, with a LC50 > 2000 mg/kg.


Based on the read across considerations same results apply to the target substance.

Justification for classification or non-classification

According to the CLP Regulation (EC n. 1272/2008), table 3.1.1, Acute toxicity hazard categories and acute toxicity estimates (ATE) defining the respective categories:


For Acute toxicity oral route:


Category 1: ATE <= 5 mg/kg bw


Category 2: 5 < ATE <= 50 mg/kg bw


Category 3: 50 < ATE <= 300 mg/kg bw


Category 4: 300 < ATE <= 2000 mg/kg bw


The LD50 of the test substance was determined to be > 2000 mg/kg bw in the chosen reference test, which is outside the limits for classification