Linalyl propionate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only the study results were provided, no study plan, no dosage information, references or further details and it dates back to 1967

Data source

Reference

Reference Type:

grey literature

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Limited data are available; however the methodology appears to be broadly comparable to standard methods (e.g. OECD 401)

GLP compliance:

no

Remarks:

study pre-dates GLP introduction

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Linalyl propionate

EC Number:

205-627-5

EC Name:

Linalyl propionate

Cas Number:

144-39-8

Molecular formula:

C13H22O2

IUPAC Name:

3,7-dimethylocta-1,6-dien-3-yl propanoate

impurity 1

Reference substance name:

Unknown impurities

Molecular formula:

not applicable

IUPAC Name:

Unknown impurities

Test material form:

liquid

Test animals

Species:

mouse

Strain:

other: CF-1

Sex:

male/female

Details on test animals or test system and environmental conditions:

CF-1 mice of both sexes weighing 17-25 grams. Ten mice were used per dose level.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

No information available

Doses:

No information available

No. of animals per sex per dose:

Ten mice were used per dose level

Control animals:

not specified

Details on study design:

CF-1 mice of both sexes weighing 17-25 grams were orally administered the compound, Ten mice were used per dose level, and the dosed animals were observed over 72 hours for mortality. LD50 values were calculated by the method of Miller and Tainter (Proc. Soc. Exptl. Biol. 57:261,1944)

Statistics:

Not reported

Results and discussion

Preliminary study:

No information available

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

13 874 mg/kg bw

Based on:

test mat.

Mortality:

Not reported

Clinical signs:

other: Not reported

Gross pathology:

Not reported

Other findings:

Not reported

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The test material is stated to be relatively non-toxic. No conclusion on classification can be made based on the results presented.

Executive summary:

CF-1 mice of both sexes weighing 17-25 grams were orally administered the compound, Ten mice were used per dose level, and the dosed animals were observed over 72 hours for mortality. The test material is stated to be relatively non-toxic LD 13,874 mg/kg; however further details are not reported.