Registration Dossier
Registration Dossier
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EC number: 692-111-1 | CAS number: 14507-43-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Justification for type of information:
- QSAR prediction
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May/July2008
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- (3S)-2-Ethyl-3-hydroxy-2-[(2E)-2-(6-methoxy-3,4-dihydronaphtalen-1(2H)-ylidene)ethyl]cyclopentanone
- EC Number:
- 692-111-1
- Cas Number:
- 14507-43-8
- Molecular formula:
- C20H26O3
- IUPAC Name:
- (3S)-2-Ethyl-3-hydroxy-2-[(2E)-2-(6-methoxy-3,4-dihydronaphtalen-1(2H)-ylidene)ethyl]cyclopentanone
- Test material form:
- solid: crystalline
- Details on test material:
- Test item: ethyl-secoolonCas No.: 14507-43-8Physical state: yellowish whiteStorage: 15-30 °C, protected from light and wet
Constituent 1
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks on result:
- other: all strains/cell types tested
Applicant's summary and conclusion
- Conclusions:
- According to (Q)SAR modell: QSAR Toolbox, the predicted value indicated that ethyl-secoolon is not mutagen.
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