Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-969-8 | CAS number: 2587-76-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1 August 1968 to 8 August 1968
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- unsuitable test system
- Remarks:
- Animals were dosed via the intraperitoneal injection which is not considered to be an appropriate route for assessing the toxicity of a chemical. It is considered that the results obtained in such a study would not provide an accurate representation of the toxicity.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The substance was administered to male and female rats via the intraperitoneal route.
- GLP compliance:
- no
- Remarks:
- Study conducted in 1968, prior to introduction of GLP.
- Limit test:
- no
Test material
- Reference substance name:
- Chlorotrioctylstannane
- EC Number:
- 219-969-8
- EC Name:
- Chlorotrioctylstannane
- Cas Number:
- 2587-76-0
- Molecular formula:
- C24H51ClSn
- IUPAC Name:
- chlorotrioctylstannane
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 100 to 130 g
- Fasting period before study: 16 to 18 hours
- Housing: 1 animal per cage, cage with a perforated floor
- Diet: ad libitum
- Water: Tap water, ad libitum
- Acclimation period: 12 days
ENVIRONMENTAL CONDITIONS
- Temperature: 21 to 23 ° C
- Humidity: 55 to 65 % (relative)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 0.5 g CMC plus 100 mL distilled water
- Details on exposure:
- - Formulation: Emulsion
- Test material concentration in vehicle: Solution I 1.8 g test material in 100 mL; Solution II 2.5 g test material in 100 mL
- Dose volumes:
90 mg/kg: .05 mL/100 g of Solution I
180 mg/kg: 1.0 mL/kg of Solution I
250 mg/kg: 1.0 mL/kg of Solution II
360 mg/kg: 2.0 mL of Solution II
500 mg/kg: 2.0 mL/kg of Solution II
720 mg/kg: 4.0 mL of Solution II - Doses:
- 90, 180, 250, 360, 500, 720 mg/kg
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: Yes. The following regions of the body were examined using the appropriate aids (e.g. magnifying glass, stereomicroscope, instruments): coat and skin, eyes, nose, mouth, ear, anus, preputial, vulva, subcutaneous tissue, stomach, pelvic cavity and peritoneum, oesophagus, small intestine, colon, mesenteric lymph nodes, liver, pancreas, spleen, kidneys, bladder, seminal vesicle, prostrate, testicle, epididymis, ovary, uterus, vagina*, chest cavity and pleura, heart, lung, trachea, thymus, cerebrum*, middle ear and application site.
Parameters marked with * only examined in cases of suspected pathology due to the intoxication or other special pathological-anatomical findings. - Statistics:
- Litchfield & Wilcoxon
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 325 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 271 - 390
- Remarks on result:
- other: calculated using Litchfield & Wilcoxon's method
- Mortality:
- At 90 and 180 mg/kg, all animals survived until the end of the observation period. In the 250 mg/kg dose group, 1 female animal died 3 days after test material administration. In the 360 mg/kg dose group, 3 female animals died 1 day after application; the remaining two females and two males died on day 2 after test material administration. In the 500 mg/kg dose group, 4 males and 5 females died 1 day after dosing, with the remaining male animal dying on day 2. In the 720 mg/kg dose group, all animals died 1 day after test material administration.
- Clinical signs:
- - At 90 and 180 mg/kg: Initial observations concluded that all 10 rats were unaffected. No clinical signs were observed throughout the seven day observation period in all 10 animals.
- At 250 mg/kg: Initial observations established all 10 rats were unaffected. Two out of the ten animals on day 1 showed signs of apathy, with the remaining 8 rats showing no clinical signs. Day 2 observations indicated 1 rat was moribund, 2 rats were showing signs of apathy and 7 animals were unaffected. Observations on day 3 found the surviving 9 rats to be unaffected. The remaining 9 animals exhibited no clinical signs on days 4 to 7.
- At 360 mg/kg: No clinical signs were observed in all ten rats at the initial observations. On day 1, 6 rats were observed to show severe signs of apathy and 1 animal was observed to show only mild signs of apathy. On days 2 and 3, the 3 surviving animals were showing signs of apathy. On day 4, these 3 rats showed moderate signs of apathy. Between days 5 to 7, these animals showed no clinical signs.
- At 500 mg/kg: Initial observations indicated that all 10 rats were unaffected. Observations on day 1 found that the surviving rat showed signs of severe apathy.
- At 720 mg/kg: Initial observation demonstrated that all ten animals showed no clinical signs. - Gross pathology:
- Observations recorded at necropsy for animals dying during the study and those sacrificed at the end of the observation period included hydrops ascites, test material remained in abdomen, haemorrhagic erosion in stomach, intestines were stuck together and hydrothorax.
A further sign observed in the sacrificed animals was swollen liver.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the study, the LC50 was determined to be 325 mg/kg with 95 % CL of 271 to 390 mg/kg in male and female rats.
- Executive summary:
The potential of the test material to cause acute toxicity via the intraperitoneal route in the rat was investigated in accordance with sound scientific principles.
The test material was administered as an emulsion using a vehicle of carboxymethylcellulose (0.5 g CMC in 100 mL distilled water) to male and female Sprague Dawley rats. The test material was administered at dose levels of 90, 180, 250, 360, 500 and 720 mg/kg to 5 animals per sex per dose.
Mortality and abnormal clinical signs were recorded initially after administration of the test material and once daily, for a period of 7 days thereafter. All animals were weighed prior to treatment. A necroscopy was performed for all the animals that died during the study and for the surviving rats on completion of the test.
No mortality and clinical signs were observed at the lower dose levels of 90 mg/kg and 180mg/kg.
In the 250 mg/kg dose group, 1 female animal died 3 days after test material administration. In the 360 mg/kg dose group, 3 female animals died 1 day after application; the remaining two females and two males died on day 2 after test material administration. In the 500 mg/kg dose group, 4 males and 5 females died 1 day after dosing, with the remaining male animal dying on day 2. In the 720 mg/kg dose group, all animals died 1 day after test material administration. The only clinical sign recorded for animals in these dose groups was apathy.
Observations recorded at necropsy for animals dying during the study and those sacrificed at the end of the observation period included hydrops ascites, test material remained in abdomen, haemorrhagic erosion in stomach, intestines were stuck together and hydrothorax. A further sign observed in the sacrificed animals was swollen liver.
Under the conditions of the study, the LC50 was determined to be 325 mg/kg with 95 % CL of 271 to 390 mg/kg in male and female rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.