Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19-23 January, 2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: A modern GLP study conducted according the appropriate guidelines.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report Date:
2004

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): Isobutyl Phenylacetate
- Molecular formula: C12H16O2
- Molecular weight: 192.2 g/mol
- Physical state: colourless liquid
- Analytical purity: 99.0 %
- Lot/batch No.: 9000466715
- Expiration date of the lot/batch: April 14, 2004

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
3.5
Temp.:
35 °C
pH:
7
Details on results:
Testing was performed at 35°C (column temperature), however the values can be considered to represent the values at an unspecified ambient temperature.

Any other information on results incl. tables

No further data

Applicant's summary and conclusion

Conclusions:
The partition coefficients n-octanol/water of Isobutyl Phenylacetate is log Pow = 3.5.
Executive summary:

The partition coefficient n-octanol/water of Isobutyl Phenylacetate was determined by the reverse HPLC method according to OECD guideline 117.

The partition coefficient n-octanol/water of Isobutyl Phenylacetate log Pow = 3.5.