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EC number: 241-379-4 | CAS number: 17354-14-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The lethal dose of the test material was above the maximum tested dose of 6400 mg/kg bw
after single, oral gavage in the rat.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Early study, no GLP, short report.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- pre-dates GLP regulation
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: SPF-Zucht: Firma Gassner, Ottobrunn, Deutschland
- Age at study initiation: no data
- Weight at study initiation: male: ca 215 g; female: ca. 155 g
- Fasting period before study: no data
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum):ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS : no data - Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2 or 16 % (w/v; suspension)
- Amount of vehicle (if gavage): max. ca. 8,6 mL
- Justification for choice of vehicle: the test material is insoluble in all possible vehicles
- Lot/batch no. (if required): no data
MAXIMUM DOSE VOLUME APPLIED: ca. 8,6 mL - Doses:
- 200 - 1600 - 3200 - 6400 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, - Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- ca. 6 400 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One male rat died about 7 days after treatment. The animal showed pneumonia during necropsy. The death was not considered as a consequence of treatment. Surviving animals also showed signs of pneumonia at necropsy.
- Clinical signs:
- other: Dyspnea and apathy were observed for 2 to 5 days.
- Gross pathology:
- The deceased animal showed pneumonia during necropsy. Surviving animals also showed signs of pneumonia at necropsy.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The lethal dose of the test material was above the maximum tested dose of 6400 mg/kg bw after single, oral gavage in the rat.
- Executive summary:
The acute oral toxicity of the test material was determined in Sprague-Dawley rats. The test material was suspended in an aqueous suspension of carboxymethyl-cellulose at 2 % (low dose) or 16 % (w/v; other doses). Doses employed were 200, 1600, 3200 and 6400 mg/kg applied orally by gavage.
The aproximate mean lethal dose (AID 50) was above 6400 rng/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 6 400 mg/kg bw
- Quality of whole database:
- reliable with restrictions (2), ealry study predates GLP,
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early sudy, no GLP, outdated methodology, limited report
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- only 1 hour exposure
- GLP compliance:
- no
- Remarks:
- pre-dates GLP regulation
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: MUS-RATTUS AG, Brunnthal, Germany
- Age at study initiation: no data
- Weight at study initiation: male: ca 315 g; female: ca. 217 g
- Fasting period before study: no data
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
no data - Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Source and rate of air: ambient air at 1 m³/h
- Method of conditioning air: no data
- System of generating particulates/aerosols: according to B. M. Wright (J.Scient. lnstrum. 27, 12 (1950): "A New Dust Feed Mechanism")
- Method of particle size determination: none
- Treatment of exhaust air: no data
- Temperature, humidity, pressure in air chamber: no data
TEST ATMOSPHERE
- Brief description of analytical method used: no data, concentrations were calculated
- Samples taken from breathing zone: no data
VEHICLE
- Composition of vehicle (if applicable): ambient air
- Concentration of test material in vehicle (if applicable): ca 4 mg/L
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: no data - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 1 h
- Concentrations:
- calculated as ca. 4 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 4 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- none
- Clinical signs:
- other: none
- Body weight:
- no data
- Gross pathology:
- no adverse findings
- Other findings:
- none
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The minimum lethal concentration after 1 hour of whole body inhalation was above 4 mg/kb bw.
- Executive summary:
The inhalation toxicity of the test material was determined in rats. Animals were exposed for 1 hour to a concentration of ca. 4 mg/L (whole body, technical maximum concentration). No adverse effects on general condition nor mortality were observed. At necropsy no effects of the test material were detected.
The mean lethal dose was above 4 mg/L in rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 4 mg/m³ air
- Quality of whole database:
- reliable with restriction (early study, predates GLP, non-standard design)
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study, no GLP; short report
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Remarks:
- pre-dates GLP regulation
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- other: white Wiener
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: BASF, Ludwigshafen, Germany
- Age at study initiation: no data
- Weight at study initiation: ca. 2,8 kg (mean)
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data - Type of coverage:
- semiocclusive
- Vehicle:
- olive oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 340 cm²
- Type of wrap if used: paper and textile
REMOVAL OF TEST SUBSTANCE
- Washing (if done):
- Time after start of exposure:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit):
- Concentration: 30 % (paste)
- Constant concentration used: yes
- For solids, paste formed: yes
VEHICLE
Olive oil
- Amount(s) applied (volume): ca 4 mL in treated and 8-9 mL in control - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- male treaded: 4
female treaded: 2
male untreaded: 1
female untreaded: 1 - Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs; other: local irritation effects - Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1 male animal died 10 days after treatment.
- Clinical signs:
- other: Temporary diarrhea, severe local blue discoloration by the test material. One male showed reduced food uptake and degraded general condition before it died after 10 days. No findings in control animals.
- Gross pathology:
- Moderately reduced to completely missing perirenal fatty tissue.
In one animal perirenal fatty tissue was well developed with blue discoloration. - Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The aproximate lethal dose was above 2000 mg/kg bw in rabbits after dermal application for 24 hours.
- Executive summary:
The acute dermal toxicity of the test material was determined in six rabbits. The material was applied at a dose os 2000 mg/kg bw (limit test) at a concentration of 30 % in olive oil und semiocclusive conditions for 24 hours. Animals developed temporary diarrhea and severe blue discoloration by the test material on the first day. One male animal died after ten days after showing reduced general condition and food uptake.
Controls did not show any effects.
The aproximate lethal dose was above 2000 mg/kg bw in rabbits after dermal application for 24 hours.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- reliable with restrictions (2), ealry study predates GLP, rabbit study
Additional information
The lethal dose of the test material was above the maximum tested dose of 6400 mg/kg bw after single, oral gavage in the rat.
The inhalation toxicity of the test material was determined in rats. Animals were exposed for 1 hour to a concentration of ca. 4 mg/L (whole body, technical maximum concentration). No adverse effects on general condition nor mortality were observed. At necropsy no effects of the test material were detected. The mean lethal concentration was above 4 mg/L in rats.
The acute dermal toxicity of the test material was determined in six rabbits. The material was applied at a dose os 2000 mg/kg bw (limit test) at a concentration of 30 % in olive oil und semiocclusive conditions for 24 hours. Animals developed temporary diarrhea and severe blue discoloration by the test material on the first day. One male animal died after ten days after showing reduced general condition and food uptake.
Controls did not show any effects.
The aproximate lethal dose was above 2000 mg/kg bw in rabbits after dermal application for 24 hours.
Justification for selection of acute toxicity – oral endpoint
only available study
Justification for selection of acute toxicity – inhalation endpoint
only available study
Justification for selection of acute toxicity – dermal endpoint
only available study
Justification for classification or non-classification
not classified;
The lethal dose of the test material was above the maximum tested dose of 6400 mg/kg bw after single, oral gavage in the rat. No adverse finding were recorded after inhalation of the maximum achievable concentration for 1 hour.
After dermal application the LD50 was greater than 2000 mg/kg bw in rabbits.
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