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Ecotoxicological information

Toxicity to microorganisms

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Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Justification for type of information:
Refer chapter 13 for the detailed analogue justification.
Qualifier:
according to guideline
Guideline:
other: Inhouse SOP (method B.10) validated by Ciba which is comparable to standard guideline.
Deviations:
not specified
Principles of method if other than guideline:
Inhouse SOP (method B.10) validated by Ciba which is comparable to standard guideline.
GLP compliance:
no
Analytical monitoring:
yes
Vehicle:
not specified
Test organisms (species):
activated sludge
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
3 h
Remarks on exposure duration:
None
Reference substance (positive control):
not specified
Key result
Duration:
3 h
Dose descriptor:
IC50
Effect conc.:
> 300 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Validity criteria fulfilled:
not specified
Conclusions:
The IC50 for FAT 40034/A was found to be greater than 300 mg/L.
Executive summary:

The toxicity of FAT 40034/A to activated sludge was determined in a 3-h respiration inhibition test according inhouse SOP (method B.10) validated by Ciba which is comparable to standard guideline. Based on the findings of the study, the IC50 of the test substance FAT 40034/A is greater than 300 mg/L.

Description of key information

The BST of the test substance Reactive Red 24:1(basis of source substance-FAT 40034/A) is greater than 300 mg/L.

Key value for chemical safety assessment

EC50 for microorganisms:
300 mg/L

Additional information

The toxicity of FAT 40034/A (source substance) to activated sludge was determined in a 3-h respiration inhibition test according In house SOP (method B.10) validated by Ciba which is comparable to standard guideline.

So, based on source substance data, the BST of Reactive Red 24:1 is greater than 300 mg/L.